La Fondation Bill & Melinda Gates annonce un soutien supplémentaire pour promouvoir la R&D locale. Appels à propositions

BRUXELLES25 octobre 2022 /PRNewswire/ — La Fondation Bill & Melinda Gates a annoncé aujourd’hui une série d’initiatives et un appel à propositions en vue de faire progresser l’innovation locale qui soutient les travaux de scientifiques et de chercheurs dans les économies en développement. L’annonce a été faite lors de la réunion annuelle de Grand Challenges plus tôt aujourd’hui.

La réunion de cette année se concentre sur les enseignements tirés de la pandémie de COVID-19, qui a mis en évidence la nécessité de plateformes de R&D à fort impact, de partenariats et de politiques qui comblent efficacement le fossé existant entre l’innovation et l’accès équitable. La réunion rapproche des chercheurs du monde entier pour partager leurs travaux, en apprendre davantage sur les avancées de pointe dans le domaine des soins de santé et permettre une collaboration avec d’autres chercheurs.

« L’équité en santé ne devrait pas uniquement être un énoncé de la raison pour laquelle nous faisons ce travail. Elle devrait guider la façon dont nous le réalisons », a déclaré Kedest Tesfagiorgis, directeur adjoint des Partenariats mondiaux et des grands défis à la Fondation Bill & Melinda Gates. « Lorsque nous soutenons l’innovation locale, nous maximisons l’impact en mettant en lumière différents types de connaissances et de perspectives. »

Dans le cadre de l’Appel mondial à l’action de Grand Challenges, une initiative sur 10 ans annoncée lors de la réunion de l’année dernière pour aider à s’assurer que les scientifiques et les institutions des pays à revenu faible et intermédiaire (PRFI) jouent un rôle central dans l’élaboration du programme mondial de R&D, deux nouvelles initiatives Grand Challenges ont été annoncée par la fondation :

  • La surveillance génomique des agents pathogènes et l’immunologie en Asie Il s’agit d’une invitation à soumission par les chercheurs en Asie du Sud et du Sud-Est pour concevoir et piloter un programme de surveillance génomique ou de développer des capacités en immunologie et séquençage immunitaire du SRAS-CoV-2 afin d’éclairer la réponse épidémique. Un montant allant jusqu’à 300 000 $ par année pour une période maximale de deux ans seront disponibles pour chaque projet, avec un financement supplémentaire potentiel pour les projets qui mettent l’accent sur la recherche d’anticorps monoclonaux.
  • Le renforcement des capacités de modélisation des données pour l’égalité des sexes  Il s’agit d’un appel à propositions lancé aux chercheurs de pays à revenu faible ou intermédiaire pour des projets visant à éliminer les disparités et les lacunes affectant les femmes et les filles dans le domaine de la santé. Cette initiative est axée sur des approches novatrices de modélisation pour faire progresser l’égalité des sexes. Chaque projet recevra jusqu’à 500 000 $ sur une période d’un à trois ans.

« Les sociétés mesurent ce qu’elles valorisent, et pour une grande partie de l’histoire, la société n’a pas valorisé les femmes. Cela signifie que nous essayons de relever des défis mondiaux en matière de santé et de développement sans disposer de toutes les informations nécessaires », a déclaré Anita Zaidi, présidente du département de l’Égalité des sexes à la Fondation Bill & Melinda Gates. « Il est grand temps de placer les femmes et les filles au centre de la modélisation des données qui guide nos solutions. »

En partenariat avec l’Initiative Chan Zuckerberg (CZI), la fondation accordera également des subventions aux chercheurs qui étudient et détectent les agents pathogènes émergents dans les PRFI. Les chercheurs recevront jusqu’à 200 000 $ chacun, pour une période maximale de deux ans, ainsi que le soutien opérationnel et une formation technique du Biohub Chan Zuckerberg  (CZ Biohub). Cet engagement de financement s’appuie sur un partenariat de 2018 entre la fondation, CZI et le CZ Biohub, qui se concentre sur le renforcement des capacités métagénomiques dans les PRFI par le biais d’une Initiative mondiale Grand Challenges.

La réunion annuelle de Grand Challenges 2022 à Bruxelles est organisée par Global Grand Challenges et la Commission européenne, et est coparrainée par Grands Défis Canada, USAID, Wellcome et la Fondation Bill & Melinda Gates.

L’événement de deux jours réunit des dizaines de leaders du paysage mondial de l’innovation en santé, ainsi que des dirigeants de la Fondation Gates, notamment Bill Gates (coprésident et administrateur), Anita Zaidi et Trevor Mundel (Président, Division de la santé mondiale). Les séances plénières seront publiées peu après la réunion sur le site grandchallenges.org/annual-meeting.

À propos de Grand Challenges

La Fondation Bill & Melinda Gates reconnaît que la résolution des défis les plus urgents en matière de santé et de développement mondiaux nécessite que davantage des esprits les plus brillants du monde y travaillent. La série d’initiatives Grand Challenges cherche à mobiliser des innovateurs du monde entier pour aider à résoudre ces défis. Les initiatives Grand Challenges sont unies par leur volonté de favoriser l’innovation, d’orienter la recherche là où elle aura le plus grand impact et d’aider ceux qui en ont le plus besoin. Pour en savoir plus, visitez le site grandchallenges.org.

À propos de la Fondation Bill & Melinda Gates

Guidée par la conviction que chaque vie a la même valeur, la Fondation Bill & Melinda Gates s’efforce d’aider toutes les personnes à mener une vie saine et productive. Dans les pays en développement, elle vise à améliorer la santé des populations et à leur donner la possibilité de ne plus souffrir de la faim et de l’extrême pauvreté. Aux États-Unis, elle vise à faire en sorte que toutes les personnes, en particulier celles qui ont le moins de ressources, aient accès aux opportunités dont elles ont besoin pour réussir à l’école et dans la vie. Basée à Seattle, Washington, la fondation est dirigée par son PDG Mark Suzman, sous la direction des coprésidents Bill Gates et Melinda French Gates et du Conseil d’administration.

Contact pour les médias : media@gatesfoundation.org

IAVI to Accelerate Promising Investigational Sudan Ebolavirus Vaccine Development for Potential Outbreak Research and Response

Merck will provide the investigational vaccine based on a proven platform technology

NEW YORK, NY / ACCESSWIRE / October 25, 2022 / IAVI, a nonprofit scientific research organization, and Merck, known as MSD outside the United States and Canada, have entered into an agreement that could enable IAVI to accelerate the entry of a promising Sudan ebolavirus (SUDV) vaccine candidate that IAVI is developing into clinical evaluation in response to the rapidly spreading outbreak of SUDV disease in Uganda.

Merck plans to produce and provide vials of candidate vaccine from existing investigational drug substance to IAVI to supplement IAVI’s ongoing SUDV vaccine development program. The investigational vaccine being produced is based on the same vesicular stomatitis virus (VSV) viral vector platform that is used in ERVEBO®, Merck’s highly efficacious, single-dose Zaire ebolavirus (EBOV) vaccine that has achieved regulatory approval by the U.S. FDA, the European Medicines Agency (EMA) and a number of regulatory authorities in Africa.

IAVI and Merck have been in discussions with the World Health Organization (WHO), the Coalition for Epidemic Preparedness Innovations (CEPI), and other stakeholders regarding the potential production and supply of doses of investigational SUDV vaccine to help support the WHO’s efforts to conduct a clinical trial of vaccine candidates in Uganda, in partnership with the Government of Uganda.

Mark Feinberg, M.D., Ph.D., president and CEO of IAVI, said, “We are grateful to Merck for supplying the vaccine material, and we look forward to the opportunity to demonstrate vaccine effectiveness and safety so that we are prepared for future outbreaks of SUDV, as well as the SUDV outbreak in Uganda should it not be promptly contained by public health measures alone. Outbreak response is more effective at containing disease spread when countermeasures work quickly, and we are hopeful that this one-dose vaccine, which is likely to generate a rapid immune response, will be a critical part of Sudan virus containment efforts in the future.”

“We are proud to work together with IAVI in support of the World Health Organization’s response to address the Sudan Ebola outbreak in Uganda,” said Beth-Ann Coller, executive director, Global Clinical Development Vaccines, Merck Research Laboratories. “We are moving with urgency to prepare these vials and donate them to IAVI as quickly as possible to help support the efforts of the WHO and the people of Uganda as they grapple with this outbreak.”

Production schedules and quantities are still being defined. Based on the quantities of available bulk drug substance and current plans, Merck hopes to be able to deliver approximately 55,000 doses by the end of the year. IAVI is actively working to accelerate the manufacture of additional doses of IAVI’s VSV-SUDV vaccine should they be needed. The number of doses provided by Merck should be sufficient for conducting Phase I and efficacy studies as well as for public health response if the outbreak in Uganda continues or spreads and should the vaccine be shown to be safe and efficacious.

IAVI will act as developer and regulatory sponsor and will be responsible for all aspects of future development of the vaccine candidate.

No SUDV vaccines have been approved to date, and existing EBOV vaccines and treatments are not effective against SUDV. In the midst of the ongoing SUDV disease outbreak, ensuring that all promising vaccine candidates are evaluated for safety and efficacy could enable vaccine stockpiles to be established for use in future outbreaks.

Vesicular stomatitis virus is the vector that underpins ERVEBO® as well as IAVI’s portfolio of emerging infectious disease vaccine candidates. These include the SUDV vaccine candidate supported by the Biomedical Advanced Research and Development Authority (BARDA) at the U.S. Department of Health and Human Services; a Lassa fever virus vaccine candidate currently in a Phase I trial and supported by the Coalition for Epidemic Preparedness Innovations (CEPI) and the European & Developing Countries Clinical Trials Partnership (EDCTP); a Marburg virus vaccine candidate supported by the Defense Threat Reduction Agency (DTRA) of the U.S. Department of Defense (DOD) and BARDA; and an intranasal SARS-CoV-2 vaccine candidate supported by the Japan Ministry of Finance. VSV is a harmless animal virus; in the vaccine platform, it is engineered to encode a surface protein from a target pathogen – in this case, SUDV – that stimulates an immune response.

IAVI holds a nonexclusive license to the VSV vaccine candidates from the Public Health Agency of Canada (PHAC). The vector was developed by scientists at PHAC’s National Microbiology Laboratory.

About IAVI

IAVI is a nonprofit scientific research organization dedicated to addressing urgent, unmet global health challenges including HIV, tuberculosis, and emerging infectious diseases. Its mission is to translate scientific discoveries into affordable, globally accessible public health solutions. Read more at iavi.org.

Funders who have made the development of IAVI’s VSV-vectored vaccine candidates possible include the Bill & Melinda Gates Foundation; the Government of Canada; the Danish Ministry of Foreign Affairs; the Government of Japan; the Irish Department of Foreign Affairs and Trade; the Netherlands Ministry of Foreign Affairs; the Norwegian Agency for Development Cooperation; the U.K Department for International Development; the U.S. National Institutes of Health (NIH); and through the generous support of the American people from the United States Agency for International Development (USAID).

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IAVI Media Contact

Karie Youngdahl
Head, Global Communications
kyoungdahl@iavi.org
+1 332-282-2890

SOURCE: IAVI

FAO advocates for scaling up the early warning and anticipatory action approaches at a regional meeting

Maputo – “When I received the SMS alert in the last week of April indicating that there was going to be heavy rain in the following three days, I was able to speed up the harvesting of sorghum crop before it got moisture damaged,” Thulani Maposa said during a review of the Early Warning Messaging Activity in her area. She is from Fumukwe (Ward 17) in Zimbabwe.

Thulani’s story is one of the several that depict the importance of early warning and anticipatory actions among farming communities.

At the Southern Africa Ministerial Meeting on Integrated Early Warning and Early Action System Initiative, the Food and Agriculture Organization of the United Nations (FAO) called on governments and partners in southern Africa to support and invest in scaling up early warning systems and anticipatory approaches for resilient agrifood systems in the region.

“Agriculture is among the most exposed sectors to these extreme weather hazards. Studies have shown that using an early warning anticipatory approach is more cost-effective than reactive approaches. FAO is committed to supporting Southern Africa Member States’ efforts to scale up actions in early warning and anticipatory action,” Patrice Talla, Subregional Coordinator for Southern Africa, told the conference.

The meeting aimed to strengthen disaster preparedness and expand early warning systems in the countries through an anticipatory approach to protect lives and livelihoods.

A shift from a reaction to prevention

The scale and complexities of these extreme hazard events, and the wide-ranging impact they have on countries, require moving from responding to preventing the impact on crops and livelihoods.

The 2021/2022 rainfall season saw six cyclonic systems bring devastating torrential rainfall that brought colossal damage to the region within a period of six weeks, including Mozambique and Madagascar. In April 2022, South Africa suffered severe flooding and landslides affecting cropland and livestock.

In Southern Africa, FAO is supporting member states in developing early warning systems. Through funding from German Federal Foreign Office in Zimbabwe, the European Union funding, and USAID funding in Tanzania, FAO has worked with government and other partners to set up contextualized early warning and short-range forecasting information systems for farming communities in the targeted group.

The farming communities receive early warning and advisories in their preferred languages, enabling them to understand better the conditions being described and make informed decisions.

Investing in early warning tools

Additionally, FAO is supporting member states in monitoring and containment of outbreaks of transboundary crop pests and animal diseases.

Working with NASA Harvest and the University of Maryland, FAO is spearheading the using earth observation tools to improve crop monitoring capabilities and to produce advanced yield forecasts in Malawi and Namibia.

In collaboration with Penn State University, FAO developed and rolled out the eLocust3m app locust early warning system in Angola, Botswana, Namibia, Zambia, and Zimbabwe. The system enables early detection of locust outbreaks.

These tools allow countries to better predict potential supply shortfalls and take well-informed decisions to support anticipatory action to protect lives and livelihoods from increasingly extreme weather and climate change impacts.

“The eLocust3m app is an innovative tool that has helped to strengthen data collection and reporting more accurately on locust infestation. Farmers and extensionists in ǁKaras Region use the app in pest control, reporting and early warning,” said Fabian Booys, an agronomist technician for the Ministry of Agriculture, Namibia.

Integrating indigenous knowledge in early warning systems

Utilizing all opportunities in early warning systems will help to forecast the likely impact, and assist relevant institutions and people at risk. There is significant potential for indigenous knowledge systems especially of farmers in the rural communities who face weather hazards and risks each day of their lives.

The Southern Africa Ministerial meeting commited to support and take an active role to ensure all citizens, in particular the most vulnerable communities in southern Africa are covered by effective Early Warning and Early Action System initiatives.

Source: Food and Agriculture Organization of the United Nations

Road to COP27: Three ways to stop the climate crisis whipping up a hunger storm

The climate crisis is pushing more and more people to the brink in a year of unprecedented hunger. Heatwaves, droughts, floods and storms are increasing in intensity and frequency, impacting people’s ability to feed their families.

In contexts such as Yemen, Somalia and the Democratic Republic of Congo, where climate impacts intersect with conflict, famine is an ever-present threat.

So, as world leaders prepare to gather in Sharm el-Sheikh in Egypt for the 2022 United Nations Climate Change Conference (COP27) between 6 and 18 November, the World Food Programme (WFP) is calling for urgent action to support those on the frontlines of the climate emergency.

Here are three things they must focus on:

1. Scale up climate adaptation and solutions to avert, minimize and address loss and damage

From devastating floods in Pakistan affecting one in seven people in the country, to consecutive droughts pushing people to the edge of famine in the Horn of Africa, extreme weather events are happening in every region of the world.

Communities need solutions to protect themselves and their ability to access enough food. Global leaders must invest in systems that predict climate hazards and provide physical and financial protection to the most vulnerable.

Ahead of recent floods in Nepal, for example, WFP triggered its anticipatory action programme — which uses early warning systems to ensure action before disasters hit — transferring cash to more than 15,000 people across three of the hardest hit districts. The funds helped communities to prepare for the floods, protect themselves and prevent losses and damages; for example, by buying food, reinforcing homes or moving vulnerable people to higher ground.

2. Invest in climate action in communities in fragile contexts

Those living on the frontlines of climate change are often also impacted by conflict, displacement and social inequalities. These communities need the most support, yet they receive the least. Over the past seven years, non-fragile states received 80 times more climate finance per person than extremely fragile states.

To tackle the climate crisis and ensure everyone has enough food to eat, we must prioritize action and funding for vulnerable and conflict-hit areas, supporting communities to adapt to a changing climate, while also building peace.

WFP projects focus on both. For instance, in Somalia earlier this year, knowing the country would continue to be gripped by extreme drought, WFP worked with the Government to deliver early-warning messages to 1.2 million people. WFP also reached 17,000 vulnerable people living in remote areas with cash transfers, to better protect their lives and livelihoods.

As Somalia faces the imminent threat of famine in parts of the country, prioritizing climate action for the most vulnerable communities is more important than ever.

3. Transform food systems

The range of activities that produce, process and transport food to our tables are neither equitable or sustainable. On the one hand, extreme weather events cause destruction right across food systems; on the other, food systems are leading contributors to global heating. Agriculture, transportation and cooking all contribute significant, harmful emissions that are raising the temperature of our planet.

The lack of diversity in our food systems, reliance on polluting practices and exposure to disruptions such as conflict, are threatening global food security. A record 345 million people in 82 countries currently face acute hunger — up from 282 million at the start of the year.

This does not need to be a downward spiral. We know the world has enough food for everyone if it were simply distributed equitably. We also have the knowledge, technology and innovative solutions to reverse the negative relationship between food systems and climate change.

What WFP is doing

Across 123 countries and territories, WFP supports communities facing some of the worst impacts of extreme weather events to build their resilience in a changing climate.

We work with local governments to anticipate climate hazards before they turn into disasters, restore degraded ecosystems and infrastructure, protect the most vulnerable with financial safety nets and give people new opportunities to farm, cook and power their homes through access to clean energy.

In five Sahel countries of West and Central Africa — Burkina Faso, Chad, Mali, Mauritania and Niger — WFP implements an integrated resilience programme that supports climate adaptation whilst also protecting food systems.

In practice this means rehabilitating land, improving peoples’ access to food and healthy diets, getting children back into school and developing value chains to boost incomes and green jobs.

For example, despite rising insecurity in the region, WFP and communities have rehabilitated nearly 158,000 hectares of degraded land in the Sahel over the past four years through initiatives like digging ‘half moons’ — which catch and keep rainfall in the soil.

With increased ambition and political will, we can diversify, decarbonize and improve the resilience of our food systems to simultaneously tackle the climate crisis and food insecurity.

World leaders have a huge challenge ahead of them, but with coordinated global action, we can tackle the climate crisis.

Source: World Food Programme

Africa Tourism Leaders Seek to Revive Sector After COVID-19


Africa’s leading tourism operators are meeting in Botswana for talks on reviving the industry after the damage caused by the COVID-19 pandemic. Intra-African travel is at the top of the agenda at the three-day meeting, which has attracted more than 450 delegates from 43 countries.

Botswana’s President Mokgweetsi Masisi, who gave the keynote speech Tuesday at the Africa Tourism Leadership Forum in Gaborone, told attendees they need to focus on ways to encourage travel to and within the continent.

“This vital forum will undoubtedly provide the travel and tourism industry in Africa — and indeed the rest of the world — with a platform for exchanging ideas aimed at promoting travel to and around Africa,” Masisi said. “Tourism is a dynamic and competitive industry that requires the ability to constantly adapt to customers’ changing needs and desires as customer satisfaction, safety and enjoyment are the focus of the tourism business.”

Masisi said tourism was showing signs of recovery after the devastating COVID-19 pandemic, which brought most vacation travel to a halt for about two years.

The president noted most African countries have eased pandemic restrictions, making it easier and more comfortable for travelers to visit.

“The sector is beginning to rebound in 2022 due to more relaxed travel restrictions and a well thought-out strategy, which saw growth of the domestic market and recovery of regional and international markets,” Masisi said.

While much of Africa looks to foreign tourism dollars, Botswana’s Tourism Minister Philda Kereng said intra-African travel was a top focus of the forum to help rebuild the industry.

“They are coming out of COVID-19 with enthusiasm, wanting to rebuild together, wanting to rebuild a resilient tourism sector that is going to build and make the economies of our countries bounce back better, and they are coming with new ideas,” Kereng said. “They are coming bubbling with energy; they want to energize the government, they want to energize every key stakeholder and player to a better way of doing business within the tourism sector.”

But poor roads and limited flights in parts of Africa too often force travel to a regional hub, or even outside the continent, for connecting flights to neighboring countries.

African tourism insiders say there are major hurdles to intra-African travel.

“One of the challenges we face on this continent is visas for ourselves as Africans, most Country A to Country B, and the second issue is connectivity,” said Kwakye Donkor, chief executive of Africa Tourism Partners, a Pan-African tourism development marketing and advisory firm. “[For instance], coming to Botswana some of them have to travel across different places, different countries to get here. And not only that, the private sector has to role play in the cost of travel, to drive this particular initiative.”

German market and consumer data company Statista says COVID-19 cost Africa’s tourism sector $87 billion when the pandemic hit in 2020.

But there are signs of a strong revival.

The United Nations World Tourism Organization says in 2022 international arrivals across Africa were up 171%.

Source: Voice of America

Security Forum Focuses on Stability Challenges in Africa

Policymakers from around the world met Monday and Tuesday in Senegal to discuss Africa’s most pressing security challenges. This year, attendees of an annual conference focused on redefining the role international partners play in promoting stability in Africa.

More than 1,000 people participated in the eighth edition of the International Forum of Dakar on Peace and Security.

Attendees included the heads of state from Liberia

, Angola and Guinea-Bissau, as well as high-ranking officials from Japan, Saudi Arabia and France.

The event opened with a speech from Senegalese President and African Union Chairman Macky Sall, who spoke about the need to re-examine modern peace operations.

If U.N. peacekeepers are being attacked on their own bases, they can’t be expected to protect local populations, he said.

“Threats to peace and stability lie in the deep economic crisis that is shaking the world,” Sall said. “Millions of people can no longer bear the cost of living, and others fall into extreme poverty, with no hope of a better future.”

The solution, he said, is to educate and create employment for Africa’s growing youth population.

The conference took place in the wake of France’s withdrawal of military forces from Mali and ongoing criticism of U.N. missions throughout the region.

Militant Islamic violence in Africa has doubled since 2019, with a record 6,300 incidents in 2022 – a 21 percent increase over last year, according to the Africa Center for Strategic Studies, a U.S. Department of Defense research group. The Sahel has been the most impacted, with violent events quadrupling over the same period.

Across the continent close to 15,000 people have died this year from extremist-linked violence, a nearly 50 percent increase from 2019.Aude Darnal, a fellow with the Stimson Center, a Washington research organization, said of the violence, “Solutions need to be defined by local actors. They also need to be implemented by local actors. International stakeholders should support, but the leadership needs to come from Africa.”

Nadia Adam, a Sahel analyst for the nonprofit Center for Civilians in Conflict, said solutions must be built from the inside. “Most African countries, especially the youth, now want to make decisions for themselves,” she said. “They want to be part of the change. And they have the capacity. More people are educated.”Government officials attending the conference reiterated that message.

Chidi Blyden is the U.S. assistant secretary of defense for African affairs. In a speech, she quoted a Creole saying from Sierra Leone, which translates to “When and if there’s a problem, look exactly where you’re standing.”

“Some of the problems reside there, but more importantly, the solution probably resides there as well,” she said. “The continent is full of African solutions to global problems.”

The forum also addressed how to decrease Africa’s dependence on international food aid and become more resistant to external shocks, such as the war in Ukraine.

Source: Voice of America